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. 2020 May 29;11(5):407. doi: 10.1038/s41419-020-2622-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Photographs of one of the KO sheep and its sibling. b There are three types of wool in the KO and the control group. c The changes in fineness of three types of wool in three different parts of KO and control group. Except for the medullated wool of the KO group at the hindquarter, the fineness of which was significantly higher than the control group, there was no significant difference in the fineness of the wools in the other parts. d Photograph of skin follicles at 48 h after shaving. The actual area shown in the picture is 16 mm². e Changes in coarse- and fine-wool density in the three parts of the KO and control group. The densities of fine wool in the KO group were significantly higher than that in the control group at all three sites. f Sacpic staining of adult sheep and lamb skin sections in the KO and control group. The ruler is marked in red in the lower-right corner of the picture. Primary, secondary, active, and inactive hair follicles are also labeled with arrows, respectively. g Changes in the total active hair-follicle ratio of coarse and fine wool between the KO and control group. Regardless of the total active hair-follicle ratio or the proportion of active primary and secondary hair follicles, the KO group was significantly higher than the control group. The statistical results in panel e are from d, and the statistical results in panel g are from f.