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. 2020 May 29;3:274. doi: 10.1038/s42003-020-0997-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic of fatty acid synthesis reaction cycle of fungal FAS. b Atomic model of S. cerevisiae FAS (PDB: 3HMJ) with six catalytic domains highlighted via surface rendering. Color coding same as panel A. c Micrograph of recombinant FAS with a 2D class shown as an inset. d NADPH consumption assay in the presence (green) and absence (black) of FAS. Red curve is in the presence of 25 μM cerulenin. Error bars are average of three independent protein preparations, each preparation assayed in technical duplicates. e cryoEM reconstruction of recombinant FAS (D3 symmetry applied) with a cross section corresponding to ACPs observed at the KS-binding sites.