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. 2020 May 29;10:8764. doi: 10.1038/s41598-020-65059-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A head-to-head comparison of LNP-formulated versus unformulated ANDV DNA vaccine. Groups of six rabbits were vaccinated with the ANDV DNA vaccine (AND-M) formulated with LNP (LUNAR®), or unformulated. (A) Experimental design legend. (B) The rabbit sera from multiple time points were assayed for neutralizing activity in the ANDV PsVNA and the results graphed by individual rabbit. (C) Group ANDV PsVNA geometric mean titer (GMT). (D) Specific differences between the GMT and coefficient of variation (%CV) per sampling day are summarized. Asterisks indicate a significant difference (p-value <0.05) between means and corresponding p-values are given. Day PI = Day Post Injection.