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. 2020 May 29;10:8764. doi: 10.1038/s41598-020-65059-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LNP-formulation of the ANDV DNA vaccine increases immunogenicity in nonhuman primates. Cynomolgus macaques were vaccinated with either 0.1 mg of LNP-formulated or unformulated ANDV DNA vaccine and boosted 28 Days later. A third group received a dose utilized in clinical studies (2.0 mg) and was boosted a second time on Day 56. (A) Legend. (B) Sera were analyzed for the presence of neutralizing antibody via a PsVNA and GMT were plotted.