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. 2020 May 29;10:8764. doi: 10.1038/s41598-020-65059-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LNP-formulated ZIKV DNA vaccine is more immunogenic than unformulated vaccine at relatively low doses. Cynomolgus macaques were vaccinated with either 0.3 mg of LNP-formulated (n = 2) or unformulated (n = 3)ZIKV DNA vaccine. The dilution of sera that reduced 50% of a 100 pfu of ZIKV, determined by a reduction in cytopathic effect (CPE) as measured by neutral red uptake. LOD: limit of detection. CPE-NR50 = the reciprocal of the dilution neutralizing CPE by 50%. Significant difference (p-value <0.05) between means and corresponding p-value is given.