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. 2020 May 29;10:8764. doi: 10.1038/s41598-020-65059-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LNP-formulation of DNA plasmid results in an increase in the amount of protein produced after intramuscular injection. Rabbit (n = 1 per group) were injected with 1.0 mg of two different DNA plasmids sharing a common backbone (pWRG7077), encoding either an anti-poxvirus human chimeric monoclonal antibody (MAb-encoded DNA) or the ANDV DNA vaccine. MAb-DNA was either formulated with LUNAR® LNP or diluted in PBS prior to injection. The ANDV DNA vaccine was LUNAR® LNP-formulated. An immunogen specific ELISA was utilized to quantitate temporal concentrations of human chimeric monoclonal antibody (c7D11) in the serum.