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. 2020 May 29;10:8764. doi: 10.1038/s41598-020-65059-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum Chemistry of LNP-formulated DNA vaccines in rabbits and nonhuman primates. Pre- and post-vaccination sera were collected. Chemistries were performed. Key analytes are shown including: (A) alanine aminotransferase, (B) aspartate aminotransferase, and (C) alkaline phosphatase. The columns are as follows (from left to right) ANDV DNA vaccine in nonhuman primates, Zika virus DNA vaccine in nonhuman primates, and ANDV DNA vaccine in rabbits. Group identifications are as followed for the first column: red circles = 0.1 mg formulated (n = 3), yellow triangles = 0.1 mg unformulated (n = 3), and purple diamonds = 2.0 mg formulated (n = 3); for the second column: purple circles = 0.3 mg formulated (n = 2), and black triangles = 0.3 mg unformulated (n = 3); for the last column: red squares = 0.1 mg formulated (n = 6), and green circles = 0.1 mg unformulated (n = 6). Mean and standard deviation are provided for nonhuman primate data. Mean and standard error of the mean are provided for rabbit data.