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. 2019 Nov 26;23(2):269–279. doi: 10.1007/s11019-019-09932-4

Table 1.

ELSI that arise from the convergence of neuroscience and genomics in the context of psychosis

Neuroscience Neuroscience and genomics Genomics
Research Neuroimaging research governance

– Return of results

– Management of Incidental Findings

– Lack of immediate clinical utility

– Challenges for REC/IRB review

– NGS research governance
Research & care

– Neuro-essentialism

– Potential applications in forensic psychiatry

– Informed consent

– Impact on identity and agency

– Privacy and confidentiality

– Data management and sharing

– Genetic essentialism
Clinical/psychiatric care – Impact on treatment options & compliance

– Stigma & self-stigmatisation

– Impact on clinician-patient relationship

– Risk assessment and communication

– Risk of over-diagnosis

– Resource allocation

– Impact on families and carers

– Regulation of genetic testing and screening

– Potential development of Direct To Consumer psychiatric genetic testing

– Risk of genetic discrimination