Table 3.
Distribution of p16 positive cases of OSCC and OPSCC with different histomorphological features associated with HPV
| Histological features | Number of cases with the feature (OSCC) | Cases positive for p16 with the feature (OSCC) | P value | Number of cases with the feature (OPSCC) | Cases positive for p16 with the feature (OPSCC) | P value |
|---|---|---|---|---|---|---|
| Nest/lobules with pushing borders | 26 | 15 | 0.0012 | 34 | 26 | 0.0001 |
| Focal basaloid appearance | 32 | 11 | 0.7678 | 25 | 19 | 0.0041 |
| Absence of stromal reaction | 9 | 5 | 0.2534 | 11 | 5 | 0.733 |
| Central necrosis | 11 | 6 | 0.1718 | 4 | 2 | 1.000 |
| Focal lymphoepithelial morphology | 4 | 3 | 0.1267 | 12 | 11 | 0.0029 |
| Presence of koilocytes | 21 | 10 | 0.2324 | 19 | 13 | 0.1478 |
| Non-keratinizing or hybrid morphology | 28 | 13 | 0.1373 | 39 | 25 | 0.0141 |
Figures in italics shows significant P value of less than 0.05