Table 2.
Results of the seven viscoelastic thromboelastography (TEG) clot parameters assessing (hyper)coagulability of whole blood (WB) and platelet poor plasma (PPP) samples from healthy individuals and colorectal cancer (CRC) patients.
| TEG WB clot parameter | Normal range | Healthy individuals (n = 28) | CRC patients (n = 26) | Unadjusted OR (99.8% CI) | Adjusted OR (99.8% CI) | Ordinal OR (99.8% CI) |
| Reaction time (R value) | 9–27 min | 8.05 [6.92–10.05] | 7.8 [6.43–8.78] | 0.87941 (0.59391–1.2433) | 0.87392 (0.57785–1.2464) | 0.91336 (0.65321–1.2483) |
| Kinetics (K value) | 2–9 min | 2.9 [2.7–3.7] | 1.65 [1.3–2.08] | 0.26064 (0.05417–0.76744) | 0.24436 (0.047616–0.75816) | 0.29566 (0.083756–0.76564) |
| Angle (A/Alpha) | 22–58° | 59.6 [55.3–62.1] | 71.8 [67.8–75.2] | 1.2317 (1.068–1.5303) | 1.245 (1.0732–1.561) | 1.1859 (1.0573–1.3768) |
| Maximum amplitude (MA) | 44–64 mm | 58.4 [54.9–62] | 70.1 [64.2–74] | 1.1224 (1.0158–1.2952) | 1.1268 (1.0178–1.3069) | 1.1128 (1.0189–1.2447) |
| Maximum rate of thrombus generation (MRTG) | 0–10 Dyn cm−2 s−1 | 4.29 [3.7–5.5] | 9.73 [6.9–12.3] | 2.0366 (1.2755–4.728) | 2.153 (1.3059–5.1693) | 1.3702 (1.1001–1.8041) |
| Time to maximum rate of thrombus generation (TMRTG) | 5–23 min | 11.2 [10.1–15] | 10.9 [8.7–12.7] | 0.87626 (0.65129–1.1299) | 0.87747 (0.64541–1.1412) | 0.89863 (0.69455–1.1313) |
| Total thrombus generation (TTG) | 25–1014 Dyn cm−2 | 703 [611–819] | 1181 [904–1437] | 1.0041 (1.0011–1.0089) | 1.0042 (1.0011–1.0093) | 1.0028 (1.0007–1.0053) |
| TEG PPP clot parameter | Healthy individuals (n = 39) | CRC patients (n = 26) | Unadjusted OR (99.8% CI) | Adjusted OR (99.8% CI) | Ordinal OR (99.8% CI) | |
| R value | 8.9 [7.85–11.2] | 8.4 [6.48–10.35] | 0.91619 (0.69394–1.1522) | 0.87447 (0.64143–1.1144) | 0.92781 (0.70967–1.1693) | |
| K value | 3.3 [2.5–4.9] | 1.45 [1.13–2.3] | 0.71491 (0.39003–1.0604) | 0.72711 (0.40712–1.0595) | 0.71052 (0.39006–1.0728) | |
| A | 56.2 [52.1–64.3] | 74.2 [65.5–77.4] | 1.2109 (1.0774–1.4523) | 1.2072 (1.0717–1.4533) | 1.1738 (1.0665–1.3287) | |
| MA | 25.5 [22.1–30.2] | 38.4 [30–45] | 1.2333 (1.0807–1.5199) | 1.2265 (1.0723–1.5132) | 1.1132 (1.0309–1.2277) | |
| MRTG | 3.51 [2.72–4.33] | 8.65 [5.38–11.9] | 1.8801 (1.2536–3.6609) | 1.7994 (1.2214–3.4995) | 1.1604 (1.011–1.4374) | |
| TMRTG | 10.8 [8.92–12.6] | 9.84 [7.25–12] | 0.9413 (0.73766–1.1502) | 0.90251 (0.68618–1.1159) | 0.95088 (0.74862–1.1649) | |
| TTG | 171 [142–217] | 312 [214–411] | 1.0194 (1.0069–1.0402) | 1.0189 (1.0062–1.0398) | 1.0059 (1.0009–1.0131) |
Data expressed as median and [25−75% quartile range]. Significant differences are shown in bold for all models.