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. 2020 May 29;11(5):405. doi: 10.1038/s41419-020-2627-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Representative IHC images and correlation analysis of IL-8, snail, and vimentin from 84 HNSCC tumor tissues (magnification 100×, 200×) are presented. Scale bar, 100 μm and 50 μm. b The relationship between IL-8, snail, and STAT3 was analyzed based on the TCGA dataset. c A schematic diagram shows that IL-8 phosphorylates PTEN to activate the STAT3/snail/EMT process and creates an IL-8/PTEN/snail positive feedback loop, which plays a critical role in HNSCC progression; *P < 0.05, **P < 0.01.