3.
单个和多个基因联合诊断效能的分析
The diagnostic efficacy of single and multiple genes combined
| Diagnosis index | Sensitivity (%) | Specificity (%) | Accuracy (%) | AUC |
| a: Combined diagnosis of CEA, CYFR211, SCC, ProGRP and NSE; b: Combined diagnosis of CDO1, CEA, CYFR211, SCC, ProGRP and NSE. CEA: carcinoembryonic antigen; CYFR21-1: cytokeratin 19 fragment; SCC: squamous cell carcinoma antigen; ProGRP: pro-gastrin releasing peptide; NSE: neuron specific endolase; AUC: area under the curve; COD1: cysteine dioxygenase 1. | ||||
| CDO1 | 52.2 | 78.6 | 65.2 | 0.635 |
| CEA | 29.0 | 95.0 | 46.0 | 0.623 |
| CYFR211 | 37.7 | 96.9 | 53.2 | 0.674 |
| SCC | 17.1 | 93.5 | 37.1 | 0.551 |
| ProGRP | 13.7 | 100.0 | 36.3 | 0.569 |
| NSE | 37.0 | 81.0 | 48.7 | 0.587 |
| Five combined checka | 69.1 | 69.4 | 69.2 | 0.691 |
| Six combined checkb | 79.2 | 70.5 | 74.9 | 0.749 |