2.

Cox regression analysis of the factors affecting OS in advanced stage NSCLC patients

Clinicopathology characteristics	Hazard ratio (HR)	HR (95%CI)		P
Gender
Male	0.83	0.39-1.76		0.626
Female	1.00
Age group
< 40 years	1.00	0.98-1.04		0.59
40-60 years	1.01
> 60 years	1.01
Smoking
Yes	1.73	0.91-3.31		0.095
No	1.00
PS
PS 3-4	3.65	-		< 0.001
PS 2	2.55	1.19-5.46
PS 1	0.76	0.26-2.17
PS 0	1.00	0.02-0.23
Clinical stage
IVb	2.99		1.63-5.27		0.0001
IVa	2.99
IIIb	1.00
Tumor (T)
T4	1.23		0.89-1.71		0.184
T3	1.23
T2	1.23
T1	1.00
Nodule (N)
N3	1.15		0.63-2.11		0.655
N2	1.15
N0	1.00
Metastasis (M)
M1b	2.96		1.58-5.52		0.0002
M1a	2.96
M0	1.00
Cancer cell type
Adenocarcinoma	1.00		0.38-1.94		0.70
Squamous cell carcinoma	0.86
EGFR mutation status
Positive	1.00		0.16-1.10		0.054
Negative	0.42
M1b metastatic type
Single	1.00		0.38-2.00		0.74
Multiple	0.88