Table 4.
Cox proportional hazards analysis of factors associated with overall survival
| Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|
| Hazard ratio | P | Hazard ratio | P | |
| Age (< 65 versus 66–75 versus > 75 years) | 0·87 (0·58, 1·30) | 0·494 | ||
| Sex (F versus M) | 1·13 (0·57, 2·21) | 0·731 | ||
| Operative approach (TTO versus THO) | 1·25 (0·69, 2·24) | 0·462 | ||
| Neutrophil to lymphocyte ratio (< 2·25 versus ≥ 2·25) | 2·33 (1·16, 4·68) | 0·017 | 2·26 (1·03, 4·93) | 0·042 |
| pT category (0 versus 1 versus 2 versus 3 versus 4) | 2·14 (1·43, 3·21) | < 0·001 | 1·81 (1·06, 3·08) | 0·029 |
| pN category (0 versus 1 versus 2 versus 3) | 1·70 (1·34, 2·15) | < 0·001 | 1·57 (1·14, 2·17) | 0·006 |
| Mandard TRG (good versus poor) | 2·67 (1·22, 5·86) | 0·014 | 4·28 (1·37, 13·34) | 0·012 |
| Differentiation (well/moderate versus poor) | 2·26 (1·27, 4·02) | 0·006 | 2·71 (1·39, 5·29) | 0·004 |
| CRM (negative versus positive) | 2·46 (1·43, 4·22) | 0·001 | 0·171 | |
| Lymph node yield (< 15 versus ≥ 15) | 0·75 (0·43, 1·31) | 0·306 | ||
Values in parentheses are 95 per cent confidence intervals. TTO, transthoracic oesophagectomy; THO, transhiatal oesophagectomy; TRG, tumour regression grade; CRM, circumferential resection margin.