Table 5.
Cox proportional hazards analysis of factors associated with disease‐free survival
| Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|
| Hazard ratio | P | Hazard ratio | P | |
| Age (< 65 versus 66–75 versus > 75 years) | 0·95 (0·59, 1·53) | 0·823 | ||
| Sex (F versus M) | 1·08 (0·49, 2·38) | 0·847 | ||
| Operative approach (TTO versus THO) | 2·64 (1·36, 5·11) | 0·004 | 3·10 (1·58, 6·12) | 0·001 |
| Neutrophil to lymphocyte ratio (< 2·25 versus ≥ 2·25) | 2·48 (1·08, 5·67) | 0·032 | 0·288 | |
| pT category (0 versus 1 versus 2 versus 3 versus 4) | 1·54 (1·09, 2·17) | 0·014 | 1·72 (1·01, 2·93) | 0·047 |
| pN category (0 versus 1 versus 2 versus 3) | 1·17 (0·98, 1·40) | 0·081 | 0·091 | |
| Mandard TRG (good versus poor) | 3·68 (1·12, 12·08) | 0·032 | 0·936 | |
| Differentiation (well/moderate versus poor) | 1·82 (0·94, 3·53) | 0·078 | 0·372 | |
| CRM (negative versus positive) | 1·38 (0·69, 2·74) | 0·361 | ||
| Lymph node yield (< 15 versus ≥ 15) | 0·71 (0·37, 1·36) | 0·302 | ||
Values in parentheses are 95 per cent confidence intervals. TTO, transthoracic oesophagectomy; THO, transhiatal oesophagectomy; TRG, tumour regression grade; CRM, circumferential resection margin.