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. Author manuscript; available in PMC: 2020 May 30.
Published in final edited form as: Annu Rev Immunol. 2020 Jan 31;38:455–485. doi: 10.1146/annurev-immunol-111319-023800

Figure 3.

Figure 3

Structures of immune pore-forming proteins. (a,c,e) Crystal structures of the monomers of (a) complement C9, (c) perforin, and (e) GSDMA3. (b,d,f) Cryo-electron microscopy reconstruction of the membrane pores formed by (b) the complement membrane attack complex, (d) perforin, and (f) GSDMA3. Abbreviations: GSDMA3, gasdermin A3; TM, transmembrane. Panels a, b, e, and f adapted from References 10, 13, 15, and 163, respectively; panels c and d adapted from Reference 9.