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. 2020 May 30;95(8):1750–1765. doi: 10.1016/j.mayocp.2020.05.011

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© 2020 Mayo Foundation for Medical Education and Research.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Pregnancy, coronavirus disease 2019 (COVID-19), and mechanisms of vascular damage. Upregulation of angiotensin-converting enzyme 2 (ACE2) receptor in pregnancy may increase the risk of severe acute respiratory syndrome coronavirus 2 infection. Binding of virus to ACE2 causes its downregulation and may increase angiotensin (Ang) II relative to Ang-(1-7), thus favoring vasoconstriction, which can mimic/worsen vascular dysfunction in preeclampsia.