Table 6.
Impacts of CCR5Δ32 on various viral infections.
| Pathogen/Disease | Population | Sample | Main findings | References |
|---|---|---|---|---|
| Poliovirus (PV) infection | Finnish | 7 PV-infected individuals with neurological symptoms;79 non-infected individuals or asymptomatic infected individuals | No association between CCR5Δ32 and severe PV-associated neurologic disease (small sample size study) | Rosenberg et al. (2013) |
| Dengue virus (DENV) infection | Brazilian | 87 DENV-infected children (severe cases); 326 controls | No statistical association between CCR5Δ32 and DENV infection | Xavier-Carvalho et al. (2013) |
| Australian | 56 DENV-infected individuals; 91 non-infected individuals | No statistical association between CCR5Δ32 and DENV infection | Brestovac et al. (2014) | |
| Indian | 42 DENV-infected individuals (33 mild cases and 9 severe cases); 90 non-infected individuals | The CCR5Δ32 allele was not detected in any individuals included in the study | Islam et al. (2019) | |
| Human cytomegalovirus (CMV) infection | European-American; African-American | 203 European-American and 117 African-American individuals with AIDS and CMV retinitis | No statistical association between CCR5Δ32 (as an individual factor) and mortality, retinitis progression or retinal detachment | Sezgin et al. (2011) |
| Polish | 72 children with intrauterine CMV infection; 398 non-infected children | No statistical association between CCR5Δ32 and CMV infection | Kasztelewicz et al. (2017) | |
| Crimean-Congo hemorrhagic fever virus (CCHFV) infection | Turkish | 3 CCHFV fatal cases; 12 CCHFV non-fatal cases | All individuals had the wild-type genotype | Engin et al. (2009) |
| Turkish | 133 CCHFV-infected individuals; 97 non-infected individuals | The CCR5Δ32 heterozygous genotype and the Δ32 allele were associated with protection against CCHFV infection (both factors found in increased frequency in control group) | Rustemoglu et al. (2017) | |
| Enterovirus (EV) infection | German | 97 individuals with enteroviral cardiomyopathy (23 individuals with persistent EV infection; 42 individuals who spontaneously cleared the virus; 32 individuals with persistent EV infection who received interferon-β therapy to clear the virus) | CCR5Δ32 was associated with spontaneous viral clearance and better clinical outcome (all Δ32 allele carriers showed viral clearance and none of them died during the study period) | Lassner et al. (2018) |
| Japanese encephalitis virus (JEV) infection | Indian | 183 JEV-infected individuals; 361 non-infected individuals | No statistical association between the CCR5Δ32 and Japanese encephalitis considering the CCR5Δ32 as an individual factor | Deval et al. (2019) |
| Nephropathia epidemica (linked to hantavirus infection) | Russian (Republic of Tatarstan) | 98 nephropathia epidemica cases; 592 controls | CCR5Δ32 did not affect susceptibility to hantavirus infection. However, the wild-type homozygous genotype was associated with more severe disease | Kletenkov et al. (2019) |