Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 25;14:2047–2060. doi: 10.2147/DDDT.S248628

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Wu et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Melatonin attenuated A/R injury in H9c2 cells by alleviating myocardial oxidative stress, decreasing MPTP opening and restoring the MMP, but these effects were lessened by 4-P-PDOT or 3-TYP and enhanced by IIK7. (A) ROS production. (B) MDA content. (C) SOD content. (D) GSH-Px level. (E) MPTP opening was determined by calcein-AM flow cytometry assay. (F) The MMP was determined by JC-1 staining. (G) Fold change in calcein-AM fluorescence. (H) The MMP is expressed as the ratio of red/green fluorescence. Data are described as the mean ± SEM (n=6 in each group). *P < 0.05 vs the control group; ^#P < 0.05 vs the A/R group; ^&P < 0.05 vs the A/R + Mel group.