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. 2020 May 25;14:2047–2060. doi: 10.2147/DDDT.S248628

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© 2020 Wu et al.

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Melatonin alleviated A/R injury in H9c2 cells by inhibiting mitophagy, but these effects were inhibited by 4-P-PDOT or 3-TYP and enhanced by IIK7. (A) Parkin expression. (B) Beclin1 expression. (C) NIX expression. (D) LC3 II/LC3 I ratio. (E) p62 expression. (F) Manders’ overlap coefficient for GFP-LC3 and mitochondria. (G) Colocalization of GFP-LC3 and MitoTracker. Fluorescence images were obtained by confocal microscopy. Data are described as the mean ± SEM (n=6 in each group). *P < 0.05 vs the control group; ^#P < 0.05 vs the A/R group; ^&P < 0.05 vs the A/R + Mel group.