Figure 1.

LDR-Induced Metabolic Rewiring in Lung Epithelial and In Situ Immune Cells Enhances the Anti-Virus Environment

LDR-induced adaptive metabolic enhancement in lung epithalamium (including ciliated cells and alveolar type I and II cells) may limit virus replication via energy competition. In addition, LDR-enhanced mitochondrial function in the immune cells (e.g., T cell, B cell, macrophages) is able to increase the immune cell activity to release cytokines to attack virus. Thus, LDR-mediated epithelial metabolism and enhanced immune cell activity coordinatively increase the anti-virus environment in the infected lungs.