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. 2020 May 30;10(7):1175–1191. doi: 10.1016/j.apsb.2020.05.009

Figure 2.

Figure 2

Vaccination of MERS S nanoparticle plus Matrix M1 protects mice from MERS-CoV challenge. (A) Neutralizing antibody levels against infections of live MERS-CoV. GMT ± standard deviation is graphed for each group of 10 mice. Dots represent individual mice. *P < 0.05, ***P < 0.001, ns means not significant. (B) Lung MERS-CoV replication was determined by plaque assay. (C) MERS-CoV specific Leader mRNA expression (D) MERS-CoV genomic RNA expression. Mean ± standard deviation are graphed for each group of 10 mice. Dots represent individual mice. LOD means limit of detection. ***P < 0.001. The figure was adapted with permission from Ref. 42. Copyright ©2017 Elsevier.