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Mice immunized with SARS-CoV spike protein amino acids 318–510 (S318–510) with alum plus CpG elicited strong antibody and cellular immune responses. (A) SARS-CoV-specific IgG antibody titers. (B) SARS-CoV-specific IgG1 and IgG2a antibody titers. (C) Neutralizing antibody levels against infections of SARS-CoV of Tor-2 strain. The figure was adapted with permission from Ref. 124. Copyright © 2007 Elsevier.
