Fig. 8.
Structural data agree on Mre11 capping domain contacting dsDNA. (A) Structure of M. jannaschii Mre11 dimer in complex with dsDNA (PDB ID: 4TUG). (B) Detail of Mre11 interface with dsDNA end in E. coli M2R2 complex in cutting state configuration (PDB ID: 6S85). Mre11 subunits are reported in green and cyan; dsDNA in grey. Basic amino acids (Lys, Arg and His) that can be implicated in DNA binding are shown as blue sticks. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)