Table 1.

Human Class A GPCRs experimental and predicted structures. The homology models were obtained from GPCRdb [23] if the sequence identity between target and template was $>$50%. Some of the human chemokine receptors structures are only in the inactive state and we also analyzed models for inactive conformations that did not have an experimental structure.

Name	Species	UNIPROT	Active	Inactive
Rhodopsin	Human	OPSD_HUMAN	6CMO	(98%)
Cannabinoid-1	Human	CNR1_HUMAN	6N4B	5U09
Cannabinoid-2	Human	CNR2_HUMAN	(66%)	5ZTY
Muscarinic M1	Human	ACM1_HUMAN	6OIJ	5CXV
Muscarinic M2	Human	ACM2_HUMAN	4MQS	3UON
Muscarinic M4	Human	ACM4_HUMAN	(91%)	5DSG
${\beta }_2$-Adrenoreceptor	Human	ADRB2_HUMAN	4LDE	2RH1
Adenosine A1	Human	AA1R_HUMAN	6D9H	5UEN
Adenosine A2A	Human	AA2AR_HUMAN	5G53	5NM4
$\delta$-Opioid	Human	OPRD_HUMAN	(82%)	4N6H
$\mu$-Opioid	Human	OPRM_HUMAN	5C1M	4DKL
$\kappa$-Opioid	Human	OPRK_HUMAN	6B73	4DJK
NOP Receptor	Human	OPRX_HUMAN	(77%)	5DHH
Serotonin 1B	Human	5HT1B_HUMAN	6G79	(60%)
Serotonin 2A	Human	5HT2A_HUMAN	(83%)	6A94
Serotonin 2B	Human	5HT2B_HUMAN	5TUD	(78%)
Serotonin 2C	Human	5HT2C_HUMAN	6BQG	6BQH
Dopamine 2 Receptor	Human	DRD2_HUMAN	(60%)	6CM4
Dopamine 3 Receptor	Human	DRD3_HUMAN	(57%)	3PBL
Dopamine 4 Receptor	Human	DRD4_HUMAN	(57%)	5WIU
Angiotensin 1	Human	AGTR1_HUMAN	6DO1	4YAY
Apelin Receptor	Human	APJ_HUMAN	(54%)	5VBL
C–C Chemokine 2	Human	CCR2_HUMAN	–	6GPX
C–C Chemokine 5	Human	CCR5_HUMAN	–	5UIX
C–C Chemokine 9	Human	CCR9_HUMAN	–	5LWE
C–C Chemokine 1	Human	CCR1_HUMAN	–	(78%)
C–C Chemokine 3	Human	CCR3_HUMAN	–	(77%)
C–C Chemokine-Like 2	Human	CCRL2_HUMAN	–	(62%)