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Details of the hotspots. For every hotspot identified, we highlight the state (active or inactive) of the hGPCR where the residue was identified, the presence of a documented function, interaction with a ligand, the existence of a mutant or variant in the GPCRdb, and the amino acid consensus. Hy indicates general hydrophobic residues; Ha, Hydrophobic aliphatic; Hb, hydrogen bonding; Sm, small. For references of the experimental data, see [11] to [100] of SI.
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