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. 2020 May 14;9(4):100422. doi: 10.1016/j.imr.2020.100422

Fig. 3.

Fig. 3

Anti-inflammatory effect of MIT in the liver of mice with NAFLD is associated with the suppression of NF-kB and MAPK signaling pathways. A) Immunohistochemistry shows p-IkB, p-ERK, and p-JNK expression in the liver of mice with NAFLD. B–D) The graph represents the number of p-IkB, p-ERK, and p-JNK immunopositive cells in each group as shown in the images in A). Abbreviations: CV, central vein; PV, portal vein; Ctrl, C57BL/6 mice fed with normal diet; HFD, C57BL/6 mice fed with high-fat diet; Met, C57BL/6 mice fed with high-fat diet and administered metformin (17 mg/kg/day) for 8 weeks; MIT, C57BL/6 mice fed with high-fat diet and administered MIT (60 mg/kg/day) extract for 8 weeks. *, P < 0.05 compared with HFD group; #, P < 0.05 compared with MIT group. Bar size, 50 μm (magnification, 200X).