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. 2020 May 14;9(4):100422. doi: 10.1016/j.imr.2020.100422

Fig. 4.

Fig. 4

Role of the mTOR signaling pathway in the effect of MIT on NAFLD. A) Immunohistochemistry shows the positive reaction of p-mTOR and PPAR-γ in the liver of NAFLD mice. Compared with the HFD group, the MIT group shows attenuated expression of p-mTOR and PPAR-γ. B–C) The graph represents the number of p-mTOR and PPAR-γ immunopositive cells in each group as shown in A). Abbreviations: CV, central vein; PV, portal vein; Ctrl, C57BL/6 mice fed with normal diet; HFD, C57BL/6 mice fed with high-fat diet; Met, C57BL/6 mice fed with high-fat diet and administered metformin (17 mg/kg/day) for 8 weeks; MIT, C57BL/6 mice fed with high-fat diet and administered MIT (60 mg/kg/day) extract for 8 weeks. *, P < 0.05 compared with HFD group; #, P < 0.05 compared with MIT group. Bar size, 50 μm (magnification, 200X).