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. 2020 May 14;9(4):100422. doi: 10.1016/j.imr.2020.100422

Fig. 5.

Fig. 5

MIT increases the antioxidant enzyme activity and exhibits scavenging activity. A) Immunohistochemistry shows the expression of GPx4 in the liver of NAFLD mice. B) The graph represents the number of GPx4 immunopositive cells as shown in A). C) MIT effectively eliminated the DPPH radical in a dose-dependent manner. Abbreviations: CV, central vein; PV, portal vein; Ctrl, C57BL/6 mice fed with normal diet; HFD, C57BL/6 mice fed with high-fat diet; Met, C57BL/6 mice fed with high-fat diet and administered metformin (17 mg/kg/day) for 8 weeks; MIT, C57BL/6 mice fed with high-fat diet and administered MIT (60 mg/kg/day) extract for 8 weeks. *, P < 0.05 compared with HFD group; #, P < 0.05 compared with MIT group. Bar size, 50 μm (magnification, 200X).