Table 2. Details of Grade 3 or Higher Immune-Related Adverse Events Seen With Initial Immune Checkpoint Inhibitor Therapy (ICI-1) and ICI Rechallenge (ICI-2).

Immune-related adverse event	No. (%)
ICI-1
Any adverse event ≥grade 3	18 (26)
Elevated liver enzymes	6 (9)
Elevated amylase/lipase	4 (6)
Pneumonitis	3 (4)
Thyroiditis	1 (1)
Hypophysitis	1 (1)
Adrenalitis	1 (1)
Hypercalcemia	1 (1)
Hypertension	1 (1)
Hypertriglyceridemia	1 (1)
ICI-2
Any adverse event ≥grade 3	11 (16)
Elevated liver enzymes	1 (1)
Elevated amylase/lipase	3 (4)
Pneumonitis	1 (1)
Arthritis	2 (3)
Colitis	1 (1)
Hyperglycemia	1 (1)
Nausea/vomiting	1 (1)
Fatigue	1 (1)