Table V.

The activity of the combination of cloxacillin, thioridazine, and miconazole against MRSA strains in vitro.

Strain	CXN	TZ	MCZ	CXN	TZ	MCZ	FICI
	MICs (Single)			MICs (Synergy)
MRSA14	512	32	2	4	4	0.25	0.26
MRSA15	512	32	2	2	4	0.25	0.25
MRSA16	512	16	4	1	4	0.25	0.31
MRSA20	256	32	2	0.25	4	0.25	0.25
MRSA21	128	16	4	0.5	4	0.25	0.32
MRSA22	64	32	4	0.25	4	0.50	0.25
MRSA25	512	16	2	0.5	4	0.50	0.50
MRSA29	256	64	4	4	4	0.50	0.20
MRSA30	512	64	4	0.5	4	0.50	0.19
MRSA64	512	32	8	8	4	0.50	0.20
MRSA65	512	32	4	0.5	4	0.50	0.25
MRSA75	512	32	2	0.5	4	0.50	0.38
MRSA76	512	32	4	8	4	0.50	0.27
MRSA92	512	16	4	0.0078	4	0.50	0.38
MRSA94	512	32	2	0.0078	4	0.50	0.38
MRSA97	256	32	2	0.0156	4	0.50	0.38
MRSA98	512	32	4	0.0078	4	0.50	0.25
MRSA125	256	16	2	0.5	4	0.50	0.50
MRSA126	256	16	1	1	4	0.50	0.75
MRSA134	512	32	1	0.0078	4	0.50	0.63
MRSA135	256	32	4	0.25	4	0.50	0.25
MRSA142	512	32	1	2	4	0.50	0.63
MRSA162	512	32	4	16	4	0.50	0.28
ATCC 29213	4	16	4	0.0156	4	0.50	0.38

See FICI criteria for details.

MCZ – miconazole; TZ – thioridazine; CXN – cloxacillin;

FIC of drug A (FIC_A) = MIC of drug A in combination / MIC of drug A alone;

FIC of drug B (FIC_B) = MIC of drug B in combination / MIC of drug B alone;

Combination FIC (AB) = Σ FIC = FIC_A + FIC_B;

Synergistic (Σ FIC ≤ 0.5);

Partially synergistic (Σ FIC > 0.5 and ≤ 1.0);

Indifferent (Σ FIC > 1 and ≤ 4);

Antagonistic (Σ FIC > 4).