Table VI.

The activity of the combination of cloxacillin, thioridazine, and miconazole against MSSA strains in vitro.

Strain	CXN	TZ	MCZ	CXN	TZ	MCZ	FICI
	MICs (Single)			MICs (Synergy)
MSSA10	16	64	4	4	4	0.25	0.38
MSSA13	8	64	8	8	4	0.25	1.09
MSSA14	8	32	2	8	4	0.25	1.25
MSSA31	16	32	2	4	4	0.25	0.50
MSSA36	16	32	1	0.015625	4	0.25	0.38
MSSA41	8	32	1	4	4	0.25	0.88
MSSA42	16	64	8	0.125	4	0.25	0.10
MSSA44	16	32	1	0.5	4	0.25	0.41
MSSA50	16	32	1	0.125	4	0.25	0.38
MSSA51	16	32	2	0.001975	4	0.25	0.25
MSSA54	16	16	2	0.0625	4	0.25	0.38
MSSA56	16	32	2	0.03125	4	0.25	0.25
MSSA62	16	32	2	0.0009715	4	0.25	0.25
MSSA65	16	32	2	0.125	4	0.25	0.26
MSSA66	16	32	4	4	4	0.25	0.44
MSSA67	16	32	4	8	4	0.25	0.69
MSSA68	16	32	4	16	4	0.25	1.19
MSSA70	16	32	4	0.015625	4	0.25	0.19
MSSA72	16	64	8	0.5	4	0.25	0.13
MSSA73	16	32	2	0.0625	4	0.25	0.25
MSSA78	8	16	2	0.03125	4	0.25	0.38
MSSA79	8	16	4	0.03125	4	0.25	0.32
MSSA80	16	32	4	0.0078125	4	0.25	0.19
ATCC 29213	4	16	4	0.0156	4	0.50	0.38

See FICI criteria for details.

MCZ – miconazole; TZ – thioridazine; CXN – cloxacillin;

FIC of drug A (FIC_A) = MIC of drug A in combination / MIC of drug A alone;

FIC of drug B (FIC_B) = MIC of drug B in combination / MIC of drug B alone;

Combination FIC(AB) = Σ FIC = FIC_A + FIC_B;

Synergistic (Σ FIC ≤ 0.5);

Partially synergistic (Σ FIC > 0.5 and ≤ 1.0);

Indifferent (Σ FIC > 1 and ≤ 4);

Antagonistic (Σ FIC > 4).