Fig. 3.

Loss of heterozygosity (LOH) and transcriptional effects associated with ancestry-specific predisposing germline variants. a LOH in ancestry-specific predisposing variants shown by comparing variant allele frequency in tumor vs. that in normal samples. Each dot denotes a variant and the affected genes are labeled in cases where showed both significant allelic imbalance and copy number deletion of the wild-type alleles (in purple). Variants showing significant allelic imbalance, yet no conclusive evidence of wild-type alleles are considered as other LOH and marked in yellow. All other variants are shown in grey. b Count distribution of each type of LOH events across genes in the African ancestry, the East Asian ancestry, and the European ancestry. Note given the larger number of events, the x-axis for the European ancestry is shown on a different scale