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. 2020 May 30;18:83. doi: 10.1186/s12951-020-00638-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — a–c In vivo antitumor effects. a Tumor volume in 4T1 tumor-bearing nude mice treated with control, S-LPNs, C-LPNs, S/C-LPNs, and S/C-pW-LPNs; *P < 0.05. b Body weight change in nude mice (mean ± SD, n = 5). c Tumor photographs. d–f in vivo anti-metastasis activity in 4T1 lung metastasis model. d Lungs of nude mice treated with control, S/C-LPNs, and S/C-pW-LPNs; H&E staining of lung tissue sections. e The number of surface metastases in the lung tissue (mean ± SD, n = 5). f Immunohistochemical (IHC) staining of CD 31, MMP-9, and TGF-β1 in tumor and lung tissue sections treated with control and S/C-pW-LPNs (scale bar = 200 μm).