Table 1.
Summary of recommendations or considerations from STROBE, ROBINS-I and Sterne et al. guidelines
Recommendation | Explanation | STROBE | ROBINS-I | Sterne et al. |
---|---|---|---|---|
Patient Selection | ||||
State eligibility criteria | State inclusion and exclusion criteria of study participants, including criteria concerning missing data | ✓ | ✓ | |
Report the number of individuals at each stage of the study | Give reasons for exclusion at each stage | ✓ | ||
Indicate the amount of individuals discarded due to missingness at each stage of the study | ✓ | ✓ | ||
Give consideration to selection bias introduced by exclusion criteria | ✓ | |||
May use a flowchart to summarise | ✓ | |||
Modelling and Covariate Selection | ||||
Covariates | Detail whether included as continuous or categorical and, if relevant, detail how the quantitative covariate was categorised | ✓ | ✓ | |
Consider departures from linearity for continuous covariates and state which transformation, if any, was used | ✓ | ✓ | ||
State analysis model | make it clear which method will be used to model the data | ✓ | ✓ | |
Covariate Selection | describe the procedure used to reach the final model | ✓ | ✓ | |
this includes, but is not restricted to, missing data imputation, transformation of covariates, interactions between covariates or inclusion of covariates for a priori reasons | ✓ | ✓ | ||
Results | Provide unadjusted estimates and the final adjusted model | ✓ | ✓ | |
State the number of participants included in unadjusted and adjusted analyses | ✓ | |||
Missing Data | ||||
Report the number of participants with missing data | Report this for each covariate of interest or the number of complete data for the important covariates | ✓ | ✓ | |
Give reasons for missing values | ✓ | ✓ | ✓ | |
Investigate if there are key differences between those observed and those with missing data - this may be compared across exposure/intervention groups. | ✓ | ✓ | ||
Missing data methods (general) | ||||
Which method was used to handle missing data? | State clearly the method used | ✓ | ✓ | ✓ |
State any missing data assumptions that were made | Such as whether the data are MCAR, MAR or MNAR | ✓ | ✓ | ✓ |
Sensitivity analysis | Should investigate robustness of findings | ✓ | ✓ | |
Compare method with a complete-case analysis | ✓ | |||
If necessary, assess validity of methods if there are differences | ✓ | ✓ | ||
Assess plausibility of missing data assumptions | ✓ | |||
Multiple Imputation | ||||
Give details of the imputation model | State the software used and key settings for imputation model | ✓ | ||
State the number of imputations used | ✓ | |||
State variables included in imputation model | ✓ | |||
State how non-normal or binary covariates were handled | ✓ | |||
Were interactions in analysis model included in imputation model? | ✓ | |||
If a large fraction of data are imputed, compare observed and imputed values | ✓ | |||
Missing data assumptions | Discuss if variables included in the imputation model make MAR assumption plausible | ✓ | ||
Sensitivity analyses | Compare MI results with CC results | ✓ | ||
Investigate departures from MAR assumption | ✓ | |||
If necessary, suggest explanations for why there are differences in results across sensitivity analyses | ✓ |