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. 2020 May 29;20:204. doi: 10.1186/s12935-020-01285-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — LATS2-AS1-001 and LATS2 expression levels are lower in GC compared with matched normal gastric mucosa. LATS2-AS1-001 and LATS2 expression levels were detected by qRT-PCR. Both LATS2-AS1-001 (a) and LATS2 (b) were downregulated in GC tissues compared with the normal gastric mucosa. The receiver operating characteristic (ROC) curves of LATS2-AS1-001 and LATS2 were constructed to assess the respective diagnostic values. Areas under curves for LATS2-AS1-001 (c) and LATS2 (d) were 0.7274 and 0.6865, respectively (P < 0.001). Correlation analysis was carried out to confirm a strong positive correlation between LATS2-AS1-001 and LATS2 mRNA expression levels (e, r = 0.719, P < 0.001). Western blot was performed to evaluate LATS2 protein expression in GC tissues. Consistent with mRNA expression, LATS2 protein levels were decreased in GC tissues compared with the normal gastric mucosa (f, g)