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. 2020 May 29;20:203. doi: 10.1186/s12935-020-01283-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The overview of m⁶A RNA methylation regulators in PTC. a A Vioplot which visualized the differentially expressed m⁶A regulators in PTC (blue represents normal tissues and red represents tumor tissues). b The mRNA levels of 19 m⁶A regulators in PTC. Red means this gene is up-regulated while green means this gene is down-regulated (*P < 0.05, **P < 0.01, ***P < 0.001). c The validation of IGF2BP2 expression level by immunohistochemical staining. The result showed that the expression level of IGF2BP2 was higher in PTC tissue than normal thyroid tissue. d Spearman correlation analysis of the 19 m⁶A regulators in PTC. The “X” represents that the correlation between this pair of genes does not have statistical significance (P > 0.05). The number in every box is the Spearman correlation coefficient between two genes