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. 2020 May 29;20:203. doi: 10.1186/s12935-020-01283-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Identification of consensus clusters by m6A regulators. a The consensus map of NMF clustering results in the total TCGA cohort. Patients were divided into cluster 1 and cluster 2 according to the expression profiles of 19 m6A regulators. b The relationship between cophenetic, dispersion, evar, residuals, rss and silhouette coefficients with respect to number of clusters. c, d The survival curve of DFS (P = 0.034) and OS (P = 0.056) in cluster 1 and cluster 2. e The correlation analysis of m6A methylation regulators and clinical phenotypes in cluster 1 and cluster 2. The result showed that these 2 clusters has statistical differences in extrathyroidal extension, T and N classifications (*P < 0.05, **P < 0.01, ***P < 0.001)