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. 2020 May 29;20:202. doi: 10.1186/s12935-020-01287-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Circ-CSPP1 positively regulated CCNE2 expression via miR-577. a Bioinformatics prediction software revealed that CCNE2 and TWF1 were targets of miR-577. b The mRNA expression levels of CCNE2 and TWF1 analyzed by qRT-PCR. c Western blotting showed the protein expression levels of CCNE2 and TWF1. d The binding sequences between miR-577 and CCNE2. e The luciferase activity of cells. f Effects of miR-577 mimics on the mRNA expression of CCNE2 was analyzed by qRT-PCR. g Western blotting showed the protein expression levels of CCNE2. (H) CCNE2 expression in HCC tissues (HCC) and adjacent non-tumor tissues (Normal). i The correlation assay showed that CCNE2 level was negatively correlated with circ-CSPP1 expression. j The correlation assay showed that CCNE2 level was positively correlated with circ-CSPP1 expression. *p < 0.05; **p < 0.01 and ***p < 0.001