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. 2020 May 29;20:205. doi: 10.1186/s12935-020-01289-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effects of LPS on HMGB1 translocation. a Western blot were performed to observe HMGB1 translocation and the results showed that LPS increased HMGB1 expression in cytoplasm but decreased the nuclear HMGB1 protein levels in SW480 and HCT116 cells. b When inhibitor Gly of HMGB1 was introduced, western blot results demonstrated that HMGB1 translocation was blocked. c IP results revealed that Gly attenuated the interaction between HMGB1 and GPX4. We investigated whether Gly have an impact on ROS levelsand NF-kB and the results showed that Gly significantly suppressed the ROS levels (d) and p-IKBα and p-p65 protein levels (e) increased by LPS. Gly, Glycyrrhizic acid