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. 2020 May 8;117(21):11541–11550. doi: 10.1073/pnas.1920761117

Fig. 3.

Fig. 3.

Schematics of possible evolutionary outcomes for latency λ. (A) The equilibrium susceptible fraction S^ has a single maximum that is an unstable evolutionarily singular strategy. In this case, there are two local stable minima of susceptible fractions at λ*=0 and λ*. Thus, this system exhibits bistability. (B) The evolutionary outcome in this case is nonzero latency, as there exists a value that minimizes the susceptible fraction, and so it is an evolutionarily stable strategy. As nearby mutants cannot invade, this is a continuously stable strategy. (C) The susceptible fraction at equilibrium is a strictly decreasing function of λ, and so the evolutionarily stable (and also continuously stable) strategy is λ*. (D) The susceptible fraction is a strictly increasing function of latency, and so the evolutionarily stable (and continuously stable) strategy is at zero latency (λ*=0).