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H+-dependent vesicular neurotransmitter transport. Specific H+-dependent transporters are responsible for neurotransmitter vesicular uptake and belong to different families depending on the global charge of their respective substrates: SLC17 for glutamate and ATP, SLC18 for monoamines and acetylcholine, and SLC32 for GABA and glycine. The driving force for the vesicular accumulation of all neurotransmitters is an H+ electrochemical gradient (∆μH+) generated by the vacuolar V-ATPase
