Fig. 2.

Putative 3D structure of GlpT and VGLUTs. The glycerol-3-phosphate transporter (GlpT) shares distant homology with members of the SLC17 family. Its 3D structure possesses two groups of 6 transmembrane helices (H1–12) linked by a large cytosolic and a luminal loop [169] (a, b). VGLUT 3D homology model based on glpT structure (pdb code 1PW4) is shown in (c, d). Key residues for glutamate transport identified so far are H128 (blue), R184 (blue), and E191 (red) located on TM2, TM4, and TM4, respectively. The software that use used to make the models was Discovery Studio Modeling Environment, release 4.5; Dassault Systems BIOVIA: San Diego, 2015