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. 2020 May 11;117(21):11703–11714. doi: 10.1073/pnas.1917130117

Table 2.

Daptomycin MICs and MBCs for VREfm isolates with mutations in lipid metabolism genes

Isolate ST Source Genotype Daptomycin MIC (µg/mL) Daptomycin MBC (µg/mL)
13-10-S 412 GI Wild type 2 16
13-14-B 412 Blood dagK(P226A) 1 2
15-10-S 412 GI Wild type 2 16
15-12-B 412 Blood dgkA (G106E) 1 2
28-10-S 736 GI Wild type 4 8 to 16
28-14-B 736 Blood dgkA (indel) 4 8 to 16
28-16-S 736 GI clsA (A20D) 8 32
28-17-B 736 Blood clsA (A20D) 8 32 to 64
31-13-S 203 GI Wild type 4 8 to 16
31-36-S 203 GI clsA (D27N) 8 32
31-38-S 203 GI clsA (D27N) 8 32
31-39-B 203 Blood clsA (D27N) 8 16

GI, gastrointestinal.