Table 2.
Maglumi, Liaison, iFlash diagnostic characteristics, considering positive or negative SARS-Cov-2 swab test in positive and negative patients (with onset > 11 gg).
|
Analytical Systems |
|||
|---|---|---|---|
| Maglumi | Liaison | iFlash | |
| N | 170 | 131 | 156 |
| AUC % (95% CI) |
96.2 (93.4–99.0) |
96.6 (93.1–100) |
95.9 (92.3–99.5) |
| Redefined thresholds | |||
| Optimized Cut-off* | 2.0 | 6.2 | 15.0 |
| Sensitivity % | 93.8 (86.0–97.9) |
97.1 (89.8–99.6) |
97.2 (90.2–99.7) |
| Specificity % | 93.3 (86.1–97.5) |
88.9 (78.4–95.4) |
85.9 (87.6–92.5) |
| LR+ (95%CI) | 29.84 (13.55–65.73) |
8.74 (4.34–17.58) |
6.88 (4.07–11.65) |
| LR- (95%CI) | 0.06 (0.03–0.15) |
0.03 (0.01–0.13) |
0.03 (0.01–0.13) |
| Classification accuracy | 93.53%, C-k = 0.870 (SE = 0.07) |
93.13%, C-k = 0.862 (SE = 0.09) |
91.0%, C-k = 0.821 (SE = 0.08) |
| Manufacturer threshold | |||
| Optimized Cut-off* | 1.1 | 15 | 10 |
| Sensitivity % | 95.0 (87.7–98.6) |
82.4 (71.2–90.5) |
93.0 (84.3–97.7) |
| Specificity % | 88.9 (80.5–94.5) |
96.8 (89.0–99.6) |
92.9 (85.3–97.4) |
| LR+ (95%CI) | 8.55 (4.76–15.37) |
25.94 (6.60–101.9) |
13.17 (6.07–28.56) |
| LR- (95%CI) | 0.06 (0.02–0.15) |
0.18 (0.11–0.31) |
0.08 (0.03–0.18) |
| Classification accuracy | 91.76% C-k = 0.835 (SE = 0.06) |
89.31% C-k = 0.787, SE = 0.08 |
92.95%, C-k = 0.858 (SE = 0.08) |
*
Youden index; C-k = Cohen’s kappa.