Table 3.
Agreement and Cohen’s kappa of the 5 analytical systems under evaluation, using the best cut-off from Youden index for CLIA methods and manufactures’ defined cut-off for Euroimmun and Wantai AbT. Seventy-nine samples were used for the comparison, only 63 samples for the Wantai AbT assay.
| IgG Ab results Performance | ||||
|---|---|---|---|---|
| Maglumi IgG | Liaison IgG | iFlash IgG | Euroimmun IgG | |
| Liaison IgG | Agreement = 93.67%Cohen’s kappa = 0.863SE = 0.112 | – | – | – |
| iFlash IgG | Agreement = 94.0%Cohen’s kappa = 0.891SE = 0.112 | Agreement = 91.1%Cohen’s kappa = 0.794SE = 0.111 | – | – |
| Euroimmun IgG | Agreement = 96.20%Cohen’s kappa = 0.919SE = 0.113 | Agreement = 97.5%Cohen’s kappa = 0.945SE = 0.112 | Agreement = 91.1%Cohen’s kappa = 0.799SE = 0.110 | – |
| Wantai AbT* | Agreement = 93.65%Cohen’s kappa = 0.849SE = 0.125 | Agreement = 98.41%Cohen’s kappa = 0.961SE = 0.126 | Agreement = 92.1%Cohen’s kappa = 0.7879SE = 0.123 | Agreement = 98.41%Cohen’s kappa = 0.962SE = 0.126 |
*
AbT = Total antibodies; SE = standard error.