. 2020 May 27;8:e8983. doi: 10.7717/peerj.8983

Table 2. Effects of STZ on hepatic gene expression.

KEGG pathway/Gene	Gene name		Type	Fold change
Toll-like receptor signaling pathway
ENSMUSG00000025498\|K09447	Irf7	Interferon regulatory factor 7	mRNA	2.58
ENSMUSG00000085667\|K00922	Gm12992	PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [Mus musculus]	processed_transcript	2.03
ENSMUSG00000021250\|K04379	FOS	Proto-oncogene protein c-fos	mRNA	0.54
ENSMUSG00000027398\|K04519	IL1B	Interleukin 1 beta	mRNA	0.48
ENSMUSG00000051439\|K04391	CD14	Monocyte differentiation antigen	mRNA	0.49
ENSMUSG00000020901\|K02649	PIK3R1_2_3	Phosphoinositide-3-kinase regulatory subunit alpha/beta/delta	mRNA	2.19
ENSMUSG00000028111\|K01371	CTSK	Cathepsin K	0.46
ENSMUSG00000112163\|K04427	MAP3K7, TAK1	Processed_pseudogene	Processed_pseudogene	0.16
Epstein-Barr virus infection
ENSMUSG00000085995\|K10591\|K09391	Gm2788	Predicted gene 2788	ncRNA	2.57
ENSMUSG00000105987\|K10591	AI506816	Expressed sequence AI506816	ncRNA	2.37
ENSMUSG00000004951\|K04455	Hspb1	Heat shock protein 1	mRNA	2.01
ENSMUSG00000019942\|K02087	Cdk1	Cyclin-dependent kinase 1	mRNA	3.04
ENSMUSG00000073406\|K06751	H2-Bl	Histocompatibility 2	mRNA	4.29
ENSMUSG00000085667\|K00922	Gm12992	Predicted gene 12992	ncRNA	2.64
ENSMUSG00000112879\|K03020	AC158802.2		Processed_pseudogene	4.41
ENSMUSG00000030724\|K06465	Cd19	CD19 antigen	mRNA	2.25
ENSMUSG00000038086\|K09543	Hspb2	Heat shock protein 2	mRNA	5.11
ENSMUSG00000113137\|K03016	AC157515.2		Processed_pseudogene	5.39
ENSMUSG00000078915\|K04455	Hsp25-ps1	Heat shock protein beta-1	mRNA	2.15
ENSMUSG00000020901\|K02649	Pik3r5	Phosphoinositide-3-kinase regulatory subunit 5	mRNA	0.41
ENSMUSG00000079507\|K06751	H2-Q1	Histocompatibility 2, Q region locus 1	mRNA	0.48
ENSMUSG00000112163\|K04427	AC158606.2		Processed_pseudogene	0.25
ENSMUSG00000092243\|K06751	Gm7030	Predicted gene 7030	ncRNA	0.18
ENSMUSG00000073405\|K06751	H2-T-ps		Unprocessed_pseudogene	0.47
ENSMUSG00000075042\|K11838	4930431P03Rik	RIKEN cDNA 4930431P03 gene	Processed_transcript	0.09
Hepatitis B
ENSMUSG00000025498\|K09447	Irf7	Interferon regulatory factor 7	mRNA	2.58
ENSMUSG00000070348\|K04503	Ccnd1	Cyclin D1	mRNA	2.74
ENSMUSG00000018983\|K09389	E2f2	E2F transcription factor 2	mRNA	2.09
ENSMUSG00000081158\|K02089	Gm13521		Processed_pseudogene	7.02
ENSMUSG00000097327\|K02091	E030030I06Rik	RIKEN cDNA E030030I06 gene	mRNA	2.43
ENSMUSG00000081121\|K04364	Gm12791		Processed_pseudogene	8.38
ENSMUSG00000085667\|K00922	Gm12992	Predicted gene 12992	ncRNA	2.64
ENSMUSG00000021250\|K04379	Fos	FBJ osteosarcoma oncogene	mRNA	0.23
ENSMUSG00000020901\|K02649	Pik3r5	Phosphoinositide-3-kinase regulatory subunit 5	mRNA	0.41
Apoptosis
ENSMUSG00000085667\|K00922	Gm12992	Predicted gene 12992	ncRNA	2.64
ENSMUSG00000026072\|K04386	Il1r1	Interleukin 1 receptor, type I	mRNA	0.50
ENSMUSG00000027398\|K04519	Il1b	Interleukin 1 beta	mRNA	0.31
ENSMUSG00000020901\|K02649	Pik3r5	Phosphoinositide-3-kinase regulatory subunit 5	mRNA	0.41
ENSMUSG00000002997\|K04739	Prkar2b	Protein kinase, cAMP dependent regulatory, type II beta	mRNA	0.48
Protein processing in endoplasmic reticulum
ENSMUSG00000057789\|K14021	Bak1	BCL2-antagonist/killer 1	mRNA	2.12
ENSMUSG00000083261\|K09502	Gm7816		Processed_pseudogene	2.10
ENSMUSG00000007033\|K03283	Hspa1l	Heat shock protein 1-like	mRNA	2.55
ENSMUSG00000100615\|K04079	Gm5511		Processed_pseudogene	7.36
ENSMUSG00000009092\|K13989	Derl3	Der1-like domain family, member 3	mRNA	0.42
ENSMUSG00000090197\|K09502	Dnaja1-ps		Processed_pseudogene	0.22
Peroxisome
ENSMUSG00000031278\|K01897	Acsl4	acyl-CoA synthetase long-chain family member 4	mRNA	2.90
ENSMUSG00000020333\|K01897	Acsl6	acyl-CoA synthetase long-chain family member 6	mRNA	3.57
ENSMUSG00000007908\|K01640	Hmgcll1	3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1	mRNA	2.12
ENSMUSG00000055782\|K05676	Abcd2	ATP-binding cassette, sub-family D (ALD), member 2	mRNA	0.09
ENSMUSG00000027870\|K11517	Hao2	Hydroxyacid oxidase 2	mRNA	0.02
ENSMUSG00000021416\|K13239	Eci3	Enoyl-Coenzyme A delta isomerase 3	mRNA	0.27
ENSMUSG00000027674\|K13342	Pex5l	Peroxisomal biogenesis factor 5-like	mRNA	0.15
ENSMUSG00000063428\|K00272	Ddo	D-aspartate oxidase, isoform CRA_a, partial [Mus musculus]	mRNA	2.35
ENSMUSG00000026272\|K00830	Agxt	Serine–pyruvate aminotransferase, mitochondrial isoform 1 precursor [Mus musculus]	mRNA	0.45
ENSMUSG00000027261\|K11517	Hao1	Hydroxyacid oxidase 1 [Mus musculus]	mRNA	2.43
ENSMUSG00000046840	Hnf4aos	Hepatic nuclear factor 4 alpha, opposite strand	ncRNA	2.19
ENSMUSG00000048482\|K04355	Bdnf	brain derived neurotrophic factor	mRNA	1.26
ENSMUSG00000085667\|K00922	Gm12992	predicted gene 12992	mRNA	2.04
ENSMUSG00000020901\|K02649	Pik3r5	phosphoinositide-3-kinase regulatory subunit 5	mRNA	0.41
ENSMUSG00000023809\|K04373	Rps6ka2	ribosomal protein S6 kinase, polypeptide 2	mRNA	0.47
ENSMUSG00000004933\|K08888	Matk	megakaryocyte-associated tyrosine kinase	mRNA	0.08
TNF signaling pathway
ENSMUSG00000085667\|K00922	Gm12992	Predicted gene 12992	ncRNA	2.64
ENSMUSG00000021367\|K16366	Edn1	Endothelin 1	mRNA	2.16
ENSMUSG00000035385\|K14624	Ccl2	Chemokine (C-C motif) ligand 2	mRNA	2.41
ENSMUSG00000034394\|K05419	Lif	Leukemia inhibitory factor	mRNA	3.06
ENSMUSG00000029380\|K05505	Cxcl1	Chemokine (C-X-C motif) ligand 1	mRNA	0.20
ENSMUSG00000053113\|K04696	Socs3	Suppressor of cytokine signaling 3	mRNA	0.37
ENSMUSG00000021250\|K04379	Fos	FBJ osteosarcoma oncogene	mRNA	0.23
ENSMUSG00000027398\|K04519	Il1b	Interleukin 1 beta	mRNA	0.31
ENSMUSG00000020901\|K02649	Pik3r5	Phosphoinositide-3-kinase regulatory subunit 5	mRNA	0.41
ENSMUSG00000058427\|K05505	Cxcl2	Chemokine (C-X-C motif) ligand 2	mRNA	0.04
ENSMUSG00000032487\|K11987	Ptgs2	Prostaglandin-endoperoxide synthase 2	mRNA	0.05
Ubiquitin mediated proteolysis
ENSMUSG00000085995\|K10591\|K09391	Gm2788	Predicted gene 2788		2.01
ENSMUSG00000105987\|K10591	AI506816	Expressed sequence AI506816	ncRNA	2.08
ENSMUSG00000006398\|K03363	Cdc20	Cell division cycle 20	mRNA	2.53
ENSMUSG00000053113\|K04696	Socs3	Suppressor of cytokine signaling 3	mRNA	0.37
ENSMUSG00000052981\|K10582	Ube2ql1	Ubiquitin-conjugating enzyme E2Q family-like 1	mRNA	0.08
ENSMUSG00000111626\|K03357	APC10, DOC1	Anaphase-promoting complex subunit 10	mRNA	0.20