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Time course experiments: genes of the Hedgehog circuit in D. melanogaster. (A) We identified critical time points from which loss or gain of function no longer has an effect on wing development for the genes ci, dpp, hh, and ptc. Remarkably, ci and hh show a similar window of activity. The phenotypes range from severe A–P polarity defects to weak vein malformation for gain-of-function (B) and loss-of-function (C) contexts.
