Table 3:
Therapies used within the 48-hour data collection window
| Day 1 MODS Absent | Day 1 MODS Present | P-value | ||||
|---|---|---|---|---|---|---|
| Therapy | NPMODS Absent N=183 | NPMODS Present N=57 | NPMODS Absent N=236 | NPMODS Present N=91 | All Groupse | NPMODS absent vs. presentf |
| Invasive mechanical ventilation | 87 (48) | 47 (82) | 209 (89) | 78 (86) | <0.001 | 0.001 |
| Vasoactive infusiona | 44 (24) | 33 (58) | 171 (72) | 66 (73) | <0.001 | 0.001 |
| Albumin | 26 (14) | 17 (30) | 62 (26) | 30 (33) | 0.001 | 0.008 |
| Blood productsb | 45 (25) | 27 (47) | 104 (44) | 56 (62) | 0.001 | <0.001 |
| Corticosteroids | 58 (32) | 26 (46) | 114 (48) | 44 (48) | 0.004 | 0.19 |
| Insulinc | 8 (4) | 8 (14) | 25 (11) | 16 (18) | 0.002 | 0.004 |
| RRTd | 7 (4) | 7 (12) | 34 (14) | 33 (36) | <0.001 | <0.001 |
Data presented as n (%).
G/GM-CSF, granulocyte/granulocyte-macrophage colony stimulating factor; IVIG, intravenous immunoglobulin; RRT, renal replacement therapy; ECMO, extracorporeal membrane oxygenation; PICC, peripherally inserted central catheter
Includes dopamine >5 mg/kg/min, dobutamine >5 mg/kg/min, or any dose of epinephrine, norepinephrine, vasopressin, phenylephrine, milrinone, levosimendan, or a vasodilator.
Includes packed red blood cells, platelets, fresh frozen plasma, cryoprecipitate, granulocytes, and whole blood.
Includes intravenous insulin by continuous infusion only.
Includes hemodialysis, all continuous renal replacement modalities, and peritoneal dialysis.
Statistical comparison across all four groups using Fisher’s exact or chi-squared tests for categorical variables
Statistical comparison between patients with NPMODS absent versus present (irrespective of day 1 MODS presence) using Fisher’s exact or chi-squared tests for categorical variables