. Author manuscript; available in PMC: 2020 May 30.

Published in final edited form as: J Med Chem. 2020 Mar 4;63(6):3381–3389. doi: 10.1021/acs.jmedchem.0c00201

Table 3.

Metabolic and solution stabilities.

Compound	The plasma stability	The microsome stability		The solution stability
Compound	The intact ± SEM at 120 (min%)	t_1/2 (min)	Clint (μL/min /mg protein)	The intact ± SEM at 120 min (%)
			Clint (μL/min /mg protein)	pH = 5.0	pH = 7.4	pH = 9.4
4	98.2 ± 6.3	14.4	96.2	92.7 ± 3.1	97.3 ± 1.1	89.1 ± 2.1
13	91.5 ± 2.5	25.3	54.8	85.9 ± 0.8	87.9 ± 3.4	89.3 ± 1.3
15	84.5 ± 10.2	57.3	24.2	87.1 ± 0.9	88.3 ± 1.9	84.3 ± 1.8
Diltiazem	49.0 ± 10.6	--	--	94.7 ± 1.4	99.0 ± 5.7	69.8 ± 2.6
Propranolol	--	3.6	390	--	--	--